ELISA Substrates and Reagents
ABclonal Technology phospho-LATS1-S909/LATS2-S872 Rabbit pAb
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
ABclonal Technology Phospho-PPP1R12A-T853 Rabbit pAb
Myosin phosphatase target subunit 1 (MBS), also known as the myosin-binding subunit, is part of myosin phosphatase, which regulates actin-myosin interaction through Rho GTPases. RhoA, in its active GTP-bound form, interacts with MBS to control myosin light chain (MLC) phosphorylation, affecting smooth muscle contraction and actin-myosin interaction in nonmuscle cells. Rho-kinase, activated by RhoA, phosphorylates MBS, inhibiting myosin phosphatase. Overexpression of RhoA increases MBS and MLC phosphorylation. This protein plays a key role in regulating actin dynamics. Multiple transcript variants encoding distinct isoforms have been identified.
Biolegend LEGENDplexTM NHP IL-1beta Ca
LEGENDplex™ NHP IL-1β Capture Bead B9, 13X Reactivity: Non-Human Primate; Apps: Multiplex - Component; Size: 100 tests (270 uL)
ABclonal Technology Phospho-MARCKS-S162 Rabbit pAb
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
Abcam TMB ELISA Substrate (Highest Sensitivity), 1000ML
Abcam's TMB ELISA Substrate (Highest Sensitive) detects horseradish peroxidase (HRP) activity and contains 3,3',5,5'-tetramethylbenzidine in a mildly acidic buffer.
The product is subject to the following: Abcam Restricted Use Statement
Abcam 650 nm Stop Solution for TMB Substrate, 100ML
Abcam's 650 nm Stop Solution for TMB Substrate is a ready-to-use solution for colorimetric HRP-based ELISA detection.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Phosphate Buffered Saline (PBS) Casein ELISA Reagent, 1000ML
Phosphate Buffered Saline (PBS) Casein ELISA Reagent is a buffer designed for ELISA assay development.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology Phospho-ERK1-T202 + ERK2-T185 Rabbit pAb
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
Biolegend PE/Cyanine7 anti-human CD235a
PE/Cyanine7 anti-human CD235a (Glycophorin A) Recombinant [QA19A08] Isotype Mouse IgG2a Reactivity Human Apps FC Size 25 tests